John Williams, MD
Disclosures: Scientific Advisory Board-Quidel|Independent Data Monitoring Committee-GlaxoSmithKline

 

John V. Williams, MD

John Williams, MD, is Henry L. Hillman Professor of Pediatrics and Chief, Division of Infectious Diseases. The major focus of his research is the immunity and pathogenesis of human metapneumovirus (HMPV). His team described the epidemiology of HMPV, a leading cause of lower respiratory infection. His lab discovered that HMPV uses integrins as receptors to enter cells through endocytosis. His group identified the HMPV F protein as a protective antigen and showed that F protein was an effective vaccine. Dr. Williams’ lab discovered that HMPV and other acute respiratory viruses induce lung CD8+ T cell impairment via the PD-1 signaling pathway, previously associated with chronic infections and cancer. Dr. Williams also leads a large CDC-funded surveillance study of acute respiratory and gastrointestinal infections in children based at Children’s Hospital of Pittsburgh, one of seven sites nationally. He is a graduate of the University of Virginia and completed medical school at the Medical College of Virginia/Virginia Commonwealth University. He trained in pediatrics at Children’s Hospital of Pittsburgh/University of Pittsburgh and in Pediatric Infectious Diseases at Vanderbilt. He has published >150 original articles, reviews, and chapters. Dr. Williams is a member of the editorial boards of the Journal of Virology and Journal of the Pediatric Infectious Disease Society. He has been an active mentor of students, residents, and fellows, and is a standing member of the NIH/NIAID MID-B Study Section. He has been recognized for his teaching and research accomplishments with the Society for Pediatric Research E. Mead Johnson Award, the Mary Ann and John Hash Award for Outstanding Teaching of Graduate Students in Microbiology and Immunology, and the inaugural Caroline B. Hall Award for Translational Research from the Pediatric Infectious Diseases Society.