Urea Cycle Disorders: The Rhythm of Progress

Friday, July 17, 2026, 8:30 AM - 3:30 PM, St. Jude Children's Research Hospital, Memphis, TN

Despite advances in diagnostics and treatment, urea cycle disorders (UCDs) and related metabolic conditions remain under-recognized by clinicians and allied health professionals. Limited exposure during training and infrequent clinical encounters contribute to delays in diagnosis, misattribution of symptoms to more common neurologic or psychiatric conditions, and inconsistent longitudinal care.

1. Recognize and diagnose urea cycle disorders across the lifespan, integrating clinical presentation, biochemical testing, and genetic evaluation to reduce time to diagnosis and improve outcomes.
2. Explain the underlying pathophysiology of urea cycle disorders, including ammonia toxicity, metabolic network disruption, and effects on brain development and function, and apply these concepts to patient management.
3. Apply evidence-based strategies for acute and long-term management of UCDs, including dietary therapy, nitrogen scavengers, neurocognitive monitoring, and transition of care.
4. Evaluate new and emerging therapies for urea cycle disorders, including gene-based, enzyme replacement, and precision medicine approaches, and discuss their implications for future clinical practice and research.

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of St. Jude Children’s Research Hospital and the Urea Cycle Disorders Consortium. St. Jude Children’s Research Hospital is accredited by the ACCME to provide continuing medical education for physicians.

AMA PRA Category 1 Credits™ (4.00 hours), Non-Physician Attendance (4.00 hours)

The faculty for this activity are listed below. Click to view the faculty member's financial disclosure information and bio. 

Mitigation of Relevant Financial Relationships

St Jude Children's Research Hospital adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers, or others, are required to disclose all financial relationships with ineligible entities (ie, companies whose primary business is producing, marketing, selling, re-selling, or distributing health care products used by or on patients). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.